Dendrittiske celler, særlig deres bruk i immunterapi mot kreft og autoimmune sykdommer.

Enkeltcelle analyser for stratifisering av pasienter og for å utvikle nye behandingsstrategier.

Medlem av organisasjonskommitteen for den årlige "Immunologiens dag" (29.4.)

 

• MED3 Immunologi-undervisning
• FARM270 Farmasøytisk mikrobiologi og immunologi
• MEDMET901 Etikk og helseforskning

Vitenskapelig artikkel

• Albin Björk; Johannes Mofors; Lauro Meneghel et al. (2025). A proteomic profile correlates with salivary gland inflammation and disease-associated antibodies in Sjögren’s disease. (ekstern lenke)
• Arnt-Ove Hovden; Marie Karlsen; Roland Jonsson et al. (2011). Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. (ekstern lenke)
• Silje Michelsen Solberg; Lene Frøyen Sandvik; Marianne Eidsheim et al. (2018). Serum cytokine measurements and biological therapy of psoriasis - Prospects for personalized treatment?. (ekstern lenke)
• Marie Karlsen; Roland Jonsson; Johan G Brun et al. (2015). TLR-7 and -9 Stimulation of Peripheral Blood B Cells Indicate Altered TLR Signalling in Primary Sjögren's Syndrome Patients by Increased Secretion of Cytokines. (ekstern lenke)
• Diana Trutschel; Pierre Bost; Xavier Mariette et al. (2022). Variability of Primary Sjögren's Syndrome Is Driven by Interferon α and Interferon α Blood Levels Are Associated With the Class II HLA–DQ Locus. (ekstern lenke)
• Aleksandra Petrovic; Victoria Marie Samuelsen-Fossen; Richard Allan Davies et al. (2024). Immune cell activity during anti-TNF treatment in patients with psoriasis and psoriatic arthritis. (ekstern lenke)
• Silke Appel; Anita Bringmann; Frank Grünebach et al. (2006). Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. (ekstern lenke)
• Richard Allan Davies; Irene Sarkar; Daniel Hammenfors et al. (2019). Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary sjogren's syndrome. (ekstern lenke)
• Waqas Azeem; Ragnhild Maukon Bakke; Silke Appel et al. (2020). Dual pro- and anti-inflammatory features of monocyte-derived dendritic cells. (ekstern lenke)
• Alexander Sauter; Yvonne Mc Duffie; Heike Böhm et al. (2015). Surface-mediated priming during in vitro generation of monocyte-derived dendritic cells. (ekstern lenke)
• Tamandeep Kaur Bharaj; Lara A. Aqrawi; Siren Fromreide et al. (2021). Inflammatory Stratification in Primary Sjögren’s Syndrome Reveals Novel Immune Cell Alterations in Patients’ Minor Salivary Glands. (ekstern lenke)
• Roman Volchenkov; Marie Karlsen; Roland Jonsson et al. (2013). Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. (ekstern lenke)
• Waqas Azeem; Ragnhild Maukon Bakke; Benjamin Gabriel et al. (2021). Evaluation of β-catenin inhibition of axitinib and nitazoxanide in human monocyte-derived dendritic cells. (ekstern lenke)
• Gülen Arsland Lied; Petra Vogelsang; Arnold Berstad et al. (2011). Dendritic cell populations in patients with self-reported food hypersensitivity. (ekstern lenke)
• Christian Lundtoft; Pascal Pucholt; Myriam Martin et al. (2022). Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases. (ekstern lenke)
• Silje Michelsen Solberg; Anders K. Aarebrot; Irene Sarkar et al. (2020). Mass cytometry analysis of blood immune cells from psoriasis patients on biological therapy. (ekstern lenke)
• Florian Sprater; Waqas Azeem; Silke Appel (2014). Activation of peroxisome proliferator-activated receptor gamma leads to upregulation of ESE-3 expression in human monocyte-derived dendritic cells. (ekstern lenke)
• Lene Frøyen Sandvik; Kathrine Skarstein; Lisbeth Sviland et al. (2013). CD11c+ dendritic cells rather than Langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients. (ekstern lenke)
• Anders Krogh Aarebrot; Silje Michelsen Solberg; Richard Allan Davies et al. (2018). Phosphorylation of intracellular signaling molecules in peripheral blood cells from psoriasis patients on originator or biosimilar infliximab. (ekstern lenke)
• Richard Allan Davies; Petra Vogelsang; Roland Jonsson et al. (2016). An optimized multiplex flow cytometry protocol for the analysis of intracellular signaling in peripheral blood mononuclear cells. (ekstern lenke)
• Cecilia Fugmann; Sarah Reid; Pascal Pucholt et al. (2024). A high polygenic risk score is associated with SSA/SSB antibody positivity and early onset in primary Sjögren’s disease. (ekstern lenke)
• Phillip Lord; Rachel Spiering; Juan C. Aguillon et al. (2016). Minimum information about tolerogenic antigen-presenting cells (MITAP): A first step towards reproducibility and standardisation of cellular therapies. (ekstern lenke)
• Nicolas Delaleu; Malin V Jonsson; Silke Appel et al. (2008). New Concepts in the Pathogenesis of Sjogren's Syndrome. (ekstern lenke)
• Magdalena Keindl; Richard Allan Davies; Brith Bergum et al. (2022). Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome. (ekstern lenke)
• Mandi M. Wiley; Marcin Radziszewski; Bhuwan Khatri et al. (2025). Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland. (ekstern lenke)
• Anke Fuchs; Mateusz Gliwiński; Nathali Grageda et al. (2018). Minimum information about T regulatory cells: A step toward reproducibility and standardization. (ekstern lenke)
• Florian Sprater; Arnt-Ove Hovden; Silke Appel (2012). Expression of ESE-3 isoforms in immunogenic and tolerogenic human monocyte-derived dendritic cells. (ekstern lenke)
• Aleksandra Petrovic; Ingvild Øye Bueide; Kåre Steinar Tveit et al. (2023). Herring roe oil in treatment of psoriasis – influence on immune cells and cytokine network. (ekstern lenke)
• Petra Vogelsang; Johan G Brun; Gunnvor Øijordsbakken et al. (2010). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. (ekstern lenke)
• Richard Allan Davies; Daniel Hammenfors; Brith Bergum et al. (2017). Patients with primary Sjögren's syndrome have alterations in absolute quantities of specific peripheral leucocyte populations. (ekstern lenke)
• Arnt-Ove Hovden; Marie Karlsen; Roland Jonsson et al. (2012). The bacterial preparation OK432 induces IL-12p70 secretion in human dendritic cells in a TLR3 dependent manner. (ekstern lenke)
• Alexander Sauter; Dag Heiro Yi; Yayan Li et al. (2019). The Culture Dish Surface Influences the Phenotype and Cytokine Production of Human Monocyte-Derived Dendritic Cells. (ekstern lenke)
• Irene Sarkar; Richard Allan Davies; Anders Krogh Aarebrot et al. (2022). Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation. (ekstern lenke)
• Marie Karlsen; Kjerstin Jakobsen; Roland Jonsson et al. (2017). Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjogren's Syndrome. (ekstern lenke)
• Silke Appel; P. Brossart (2007). Development of novel compounds to treat autoimmune and inflammatory diseases and graft versus host reactions. (ekstern lenke)
• Alexander Sauter; Gunther Richter; Alexandre Micoulet et al. (2013). Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets. (ekstern lenke)
• Petra Vogelsang; Marie Karlsen; Johan G Brun et al. (2014). Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome. (ekstern lenke)
• Magdalena Keindl; Olena Fedotkina; Elsa du Plessis et al. (2020). Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms. (ekstern lenke)
• Karstein Haldorsen; Silke Appel; Stephanie Le Hellard et al. (2013). No association of primary Sjögren's syndrome with Fcγ receptor gene variants. (ekstern lenke)
• Gunnel Nordmark; Gudlaug Kristjansdottir; Elke Theander et al. (2011). Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome. (ekstern lenke)
• Silke Appel; Stephanie Le Hellard; Ove Bruland et al. (2011). Potential association of muscarinic receptor 3 gene variants with primary Sjögren's syndrome. (ekstern lenke)
• Richard Allan Davies; Daniel Hammenfors; Brith Bergum et al. (2018). Aberrant cell signalling in PBMCs upon IFN-? stimulation in primary Sjogren's syndrome patients associates with type I interferon signature. (ekstern lenke)
• Lene Frøyen Sandvik; Roman Volchenkov; Roland Jonsson et al. (2013). Characterization of monocyte-derived dendritic cells from immunosuppressed renal transplant recipients with and without squamous cell carcinomas. (ekstern lenke)
• Dag Heiro Yi; Nadine Stetter; Kjerstin Jakobsen et al. (2018). 3-Day monocyte-derived dendritic cells stimulated with a combination of OK432, TLR7/8 ligand, and prostaglandin E2 are a promising alternative for cancer immunotherapy. (ekstern lenke)
• Petra Vogelsang; Arnt-Ove Hovden; Roland Jonsson et al. (2009). Levels of dendritic cell populations and regulatory T cells vary significantly between two commonly used mouse strains. (ekstern lenke)
• Muhammad Rahman; André Sulen; Lars Ertesvåg Breivik et al. (2025). Anti-perilipin-1 autoantibodies in autoimmune Addison’s disease and related endocrine disorders. (ekstern lenke)
• Lene Frøyen Sandvik; Kathrine Skarstein; Britta Krynitz et al. (2015). Peritumoral dermis of squamous cell carcinomas in renal transplant recipients contains less CD11c+ myeloid dendritic cells and FoxP3+ T cells compared to immunocompetent controls. (ekstern lenke)
• Ole J. B. Landsverk; Anett Hellebø Ottesen; Axel Berg-Larsen et al. (2012). Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells. (ekstern lenke)
• Roman Volchenkov; Johan G Brun; Roland Jonsson et al. (2013). In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome. (ekstern lenke)
• Marie Karlsen; Arnt-Ove Hovden; Petra Vogelsang et al. (2011). Bromelain Treatment Leads to Maturation of Monocyte-derived Dendritic Cells but Cannot Replace PGE(2) in a Cocktail of IL-1 beta, IL-6, TNF-alpha and PGE(2). (ekstern lenke)
• Marie Karlsen; Torbjørn Hansen; Hilde Haugedal Nordal et al. (2015). Expression of toll-like receptor -7 and -9 in B cell subsets from patients with primary Sjögren's syndrome. (ekstern lenke)

Konferanseabstrakt

• Roman Volchenkov; Arnt-Ove Hovden; Marie Karlsen et al. (2011). Generation of Tolerogenic Monocyte-Derived Dendritic Cells. (ekstern lenke)
• Marie Karlsen; Torbjørn Hansen; Roland Jonsson et al. (2012). Expression of Toll-like receptors 7 and 9 in B cell populations of patients with Sjogren's syndrome. (ekstern lenke)
• Gülen Arsland Lied; Petra Vogelsang; Arnold Berstad et al. (2010). Dendritic cell populations in patients with self-reported food hypersensitivity. (ekstern lenke)
• Roman Volchenkov; Marie Karlsen; Roland Jonsson et al. (2013). Type 1 Regulatory T cells and Regulatory B Cells Induced by Dexamethasone and 1,25-Dihydroxyvitamin D3 Treated Monocyte-Derived Dendritic Cells. (ekstern lenke)
• Petra Vogelsang; Virginie Deswaerte; Malin V Jonsson et al. (2008). Age-related distribution of cDC and pDC in salivary glands of NOD mice. (ekstern lenke)
• Arnt-Ove Hovden; Dagny Ann Sandnes; Roland Jonsson et al. (2008). Maturation of monocyte derived dendritic cells with OK432 leads to altered expression of surface markers. (ekstern lenke)
• Karstein Haldorsen; Silke Appel; Ove Bruland et al. (2010). Fc gamma receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc gamma receptor IIIB copy number variation: No association with primary Sjögren's syndrome. (ekstern lenke)
• Karstein Haldorsen; Silke Appel; Stephanie Le Hellard et al. (2012). No association of primary Sjögren's Syndrome with Fc gamma? Receptor gene variants. (ekstern lenke)
• Marie Karlsen; Arnt-Ove Hovden; Petra Vogelsang et al. (2010). Bromelain Treatment Leads to Maturation of Monocyte Derived Dendritic Cells. (ekstern lenke)
• Lene Frøyen Sandvik; Torbjørn Leivestad; Dagny Ann Sandnes et al. (2011). Can Levels of Blood Plasmacytoid Dendritic Cells be used as a Prognostic Factor for Development of Squamous Cell Carcinomas in Organ Transplant Recipients?. (ekstern lenke)
• Silke Appel; Petra Vogelsang; Johan G Brun et al. (2010). Patients with Primary Sjogren's Syndrome have Significantly Reduced Amounts of Plasmacytoid and Type 2 Myeloid Dendritic Cells in Peripheral Blood. (ekstern lenke)
• Roman Volchenkov; Marie Karlsen; Roland Jonsson et al. (2012). Comparison of different protocols for the generation of monocytes-derived tolerogenic dendritic cells for immunotherapy. (ekstern lenke)
• Anita Bringmann; Ingo Hilgendorf; Silke Appel et al. (2008). Characterization of Gene p306 Expressed in Monocyte Derived Dendritic Cells. (ekstern lenke)
• Gunnel Nordmark; Gudlaug Kristjansdotti; Elke Theander et al. (2010). Gene Variants in Fam167A-Blk and Tnfsf4 are associated with Primary Sjogren's Syndrome. (ekstern lenke)
• Florian Sprater; Arnt-Ove Hovden; Marc Niere et al. (2011). The Epithelial Specific Transcription Factor ESE-3 is Expressed in Immature Dendritic Cells and Occurs Primarily as the ESE-3b Isoform. (ekstern lenke)
• Arnt-Ove Hovden; Marie Karlsen; Roland Jonsson et al. (2011). Maturation of Dendritic Cells with the Bacterial Compound OK432 Induces High Secretion of IL-12p70 in a TLR3 Dependent Manner. (ekstern lenke)
• Arnt-Ove Hovden; Marie Karlsen; Dagny Ann Sandnes et al. (2010). Maturation of Monocyte Derived Dendritic Cells With OK432 Leads to Altered Expression of Surface Markers. (ekstern lenke)

Leserbrev

• Arnt-Ove Hovden; Silke Appel (2010). The First Dendritic Cell-Based Therapeutic Cancer Vaccine is Approved by the FDA. (ekstern lenke)
• Aleksandra Petrovic; Lisa Lynn Ten Bergen; Silje Michelsen Solberg et al. (2023). Biological treatment in severe psoriasis: Influence on peripheral blood dendritic cells. (ekstern lenke)
• Roman Volchenkov; Roland Jonsson; Silke Appel (2012). Anti-Ro and anti-La autoantibody profiling in Norwegian patients with primary Sjogren's syndrome using luciferase immunoprecipitation systems (LIPS). (ekstern lenke)
• Karstein Haldorsen; Ove Bruland; Silke Appel et al. (2013). Reply to 'Comment on No association of primary Sjogren's syndrome with Fc gamma receptor gene variants'. (ekstern lenke)
• Lene Frøyen Sandvik; Petra Vogelsang; Torbjørn Leivestad et al. (2012). Quantification of Plasmacytoid Dendritic Cells and Type 1 Myeloid Dendritic Cells in Peripheral Blood of Renal Transplant Recipients With and Without Squamous Cell Carcinoma. (ekstern lenke)

Konferanseposter

• Aina van der Meeren; Silke Appel; Gülen Arslan Lied et al. (2023). Diagnostic gut biomarkers with imaging mass cytometry in irritable bowel syndrome. (ekstern lenke)
• Gunnel Nordmark; Gudlaug Kristjansdottir; Silke Appel et al. (2009). Association of C8orf13-BLK and TNFSF4 Gene Variants with Primary Sjögren's Syndrome. (ekstern lenke)
• Petra Vogelsang; Johan G Brun; Roland Jonsson et al. (2009). Levels of plasmacytoid dendritic cells and type-2 myeloid dendritic cells are reduced in peripheral blood of patients with primary Sjögren's syndrome. (ekstern lenke)
• Petra Vogelsang; GS Lier; Johan G Brun et al. (2009). Dendritic cells from patients with primary Sjögren's syndrome have slightly enhanced endocytic capacity. (ekstern lenke)
• Aina Van Der Meeren; Silke Appel; Gülen Arslan Lied et al. (2023). Bergen BrainGut study: diagnostic gut biomarkers in irritable bowel syndrome with imaging mass cytometry. (ekstern lenke)
• Aina van der Meeren; Silke Appel; Gülen Arslan Lied et al. (2024). Mapping of the duodenal mucosal microenvironment in iriitabel bowel syndrome with imaging mass cytometry. (ekstern lenke)
• Karstein Haldorsen; Silke Appel; Ove Bruland et al. (2009). Fc receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fc receptor IIIB copy number variation: No association with primary Sjögren’s syndrome. (ekstern lenke)

Medieintervju

• Ivar Lid Riise; Mathias Kleiveland; Heidi Lie Andersen et al. (2023). Dreper kreftceller med hageplanter. (ekstern lenke)

Konferanseforedrag

• Dorentina Osmani; Manpret Kour Hans; Kjerstin Jakobsen et al. (2023). Planter vs. dødelig virus. (ekstern lenke)

Vitenskapelig litteraturgjennomgang

• Lisa Lynn Ten Bergen; Aleksandra Petrovic; Anders K. Aarebrot et al. (2020). Current knowledge on autoantigens and autoantibodies in psoriasis. (ekstern lenke)
• Lisa Lynn Ten Bergen; Aleksandra Petrovic; Anders K. Aarebrot et al. (2020). The TNF/IL-23/IL-17 axis-Head-to-head trials comparing different biologics in psoriasis treatment. (ekstern lenke)
• Roland Jonsson; Petra Vogelsang; Roman Volchenkov et al. (2011). The complexity of Sjögren's syndrome: Novel aspects on pathogenesis. (ekstern lenke)
• Dag Heiro Yi; Silke Appel (2013). Current status and future perspectives of dendritic cell-based cancer immunotherapy. (ekstern lenke)
• Petra Vogelsang; Malin V Jonsson; Sussie Trine Dalvin et al. (2006). Role of dendritic cells in Sjögren´s syndrome. (ekstern lenke)
• Roman Volchenkov; Florian Sprater; Petra Vogelsang et al. (2012). The 2011 Nobel Prize in physiology or medicine. (ekstern lenke)

Doktorgradsavhandling

• Silje Michelsen Solberg; Silke Appel; Yenan Bryceson et al. (2019). Systemic inflammation in psoriasis: Circulating immune cells and cytokines. (ekstern lenke)
• Marie Karlsen; Silke Appel; Torbjørn Hansen (2015). Toll-like receptors in primary Sjögren’s syndrome. Special emphasis on B cells. (ekstern lenke)
• Richard Allan Davies; Silke Appel; Petra Vogelsang et al. (2017). Flow cytometry based analyses as a tool in biomarker discovery for patient stratification in primary Sjögren’s syndrome. (ekstern lenke)
• Karstein Haldorsen; Anne Isine Bolstad; Johan G Brun et al. (2011). Epidemiological, clinical, and immunogenetic aspects of primary Sjögren's syndrome. (ekstern lenke)

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